To continue our exploration of the quantum physics of wound healing I want to take a long detour into quantum phenomena (clinicians bear with me, no math involved, I promise). Let’s start with the phenomenon of quantum entanglement first described by Einstein and his colleagues in 1935, further elaborated by Schrödinger, and which became known
The Quantum Physics of Wound Healing
In our prior blog Prior Belief Systems, Placebos, Nocebos, and Wound Healing we talked about various belief systems in regard to wound care. However, there is another elephant in the room that we have not mentioned and that is the frequency that a patient visits a clinic; in research parlance this would be visit frequency.
I talked before about clinical equipoise but one issue that was avoided is belief systems. Over the years I have listened to a lot of anecdotal stories about wound care clinicians who were quite convinced that healing the patient’s wound would not be a big deal but the patient was convinced it wasn’t going to
Equipoise is something we don’t discuss enough when it comes to designing clinical trials. Fries and Krishhnan quoting Djulbegovic et al define equipoise as: participants will not suffer relative harm from random assignment to a particular treatment arm; the results of a study cannot be predicted consistently in advance; and over a number of RCTs
Health economics is the study of medical procedures, drugs, or devices, in terms of cost and outcomes. Although there are many approaches, the most common is cost effectiveness (CE). In this kind of study, the introduction of a medical procedure, drug, or device is examined in terms of its added cost in relation to an
Here are some of the fruits of our latest book chapters recently published or in press: Fife CE, Carter MJ. Lipolymphema. In: Color Atlas and Synopsis of Vascular Disease (Eds: S. Dean and B. Satiani). New York: McGraw Hill, 2014:327-32. Phillips BJ, Carter MJ. Changes to the hypothalamic-pituitary-adrenal axis in burns and use of steroids.
Here are some of the fruits of our latest research–papers recently published or in press: Carter MJ. Economic evaluations of guideline-based or strategic Interventions for the prevention or treatment of chronic wounds: a systematic review. Applied Health Economics Health Policy; 2014 in press. Carter MJ. Health economics information in wound care: The elephant in the
New to clinical trials or studies? We want you to feel you have come to the right place. Contemplating a clinical trial or study can be daunting, so we can walk you all the steps before you start to ensure that whatever you are planning, it will meet all your goals. Need some specialist help?
At SAWC, which is one the largest wound care meetings, held this year in Dallas, we presented or co-presented two papers, one with Drs Tom Serena and Barbara Bates-Johnson on the principles of wound care research, and with Dr. Caroline Fife and her colleagues at Intellicure on the cost of outpatient wound care.
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Design Studies
Over the last several years we have critiqued hundreds of clinical studies either informally or as part of a systematic review. In every instance we have come across problems — some small, but many that can be regarded as design flaws. We cannot fix design flaws! What we can do, however, is help you plan a study so that it doesn’t have any. Click on our Clinical Design of Studies page.
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